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New combination treatment targets pre-leukemia stem cells
When hematopoietic stem cells mutate in specific ways, the result can be damaged stem cells that create a type of pre-leukemic condition known as myelodysplastic syndrome, or MDS. It shows that drugs that target these processes result in the death of MDS stem cells, while leaving healthy blood stem cells unharmed. Interestingly, these pre-leukemia stem cells were making many more proteins without making many more cells.
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