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How a virus destabilizes the genome
KSHV is associated with human malignancies and disorders marked by the excessive growth of white blood cells. KSHV-associated diseases are characterized by genetic alterations driven by chromosomal instability, as seen in numerous viral-associated cancer cells. In the new study, Robertson and colleagues addressed this question by examining the molecular underpinnings of KSHV-induced chromosomal instability. Specifically, this protein disrupts chromosome stability by inhibiting Bub1 phosphorylation of H2A and Cdc20, resulting in the dislocation of Shugoshin-1.
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