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Cancer drug and antidepressants provide clues for treating brain-eating amoeba infections
The amoeba Naegleria fowleri is commonly found in warm swimming pools, lakes and rivers. On rare occasions, the amoeba can infect a healthy person and cause severe primary amebic meningoencephalitis, a brain-eating disease that is almost always fatal. Several of these drugs are already approved by the US Food and Drug Administration for other uses, such as antifungal agents, the breast cancer drug tamoxifen and antidepressant Prozac. In other words, combination treatment allowed them to inhibit more of the pathogen using lower drug concentrations.
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